Neurobiology of Disease Mitochondrial Dysfunction in SOD1-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants
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چکیده
Patricia Cassina,1,3* Adriana Cassina,2,3* Mariana Pehar,4 Raquel Castellanos,1 Mandi Gandelman,1,5 Andrés de León,1,5 Kristine M. Robinson,7 Ronald P. Mason,6 Joseph S. Beckman,7 Luis Barbeito,3,4,5 and Rafael Radi,2,3 1Departamento de Histologı́a, 2Departamento de Bioquı́mica, and 3Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay, 4Instituto de Investigaciones Biológicas Clemente Estable, 11600 Montevideo, Uruguay, 5Neurodegeneration Laboratory, Institut Pasteur, 11400 Montevideo, Uruguay, 6Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina 27709, and 7Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331
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تاریخ انتشار 2008